To provide accurate and explainable misinformation detection, it is often useful to take an auxiliary source (e.g., social context and knowledge base) into consideration. Existing methods use social contexts such as users’ engagements as complementary information to improve detection performance and derive explanations. However, due to the lack of sufficient professional knowledge, users seldom respond to healthcare information, which makes these methods less applicable. In this work, to address these shortcomings, we propose a novel knowledge guided graph attention network for detecting health misinformation better. Our proposal, named as DETERRENT, leverages on the additional information from medical knowledge graph by propagating information along with the network, incorporates a Medical Knowledge Graph and an Article-Entity Bipartite Graph, and propagates the node embeddings through Knowledge Paths. In addition, an attention mechanism is applied to calculate the importance of entities to each article, and the knowledge guided article embeddings are used for misinformation detection. DETERRENT addresses the limitation on social contexts in the healthcare domain and is capable of providing useful explanations for the results of detection. Empirical validation using two real-world datasets demonstrated the effectiveness of DETERRENT. Comparing with the best results of eight competing methods, in terms of F1 Score, DETERRENT outperforms all methods by at least 4.78% on the diabetes dataset and 12.79% on cancer dataset. We release the source code of DETERRENT at: https://github.com/cuilimeng/DETERRENT.